The Oscar-winning actress will portray the dog-hating villain in Cruella, an upcoming live-action prequel to 101 Dalmatians, which only began filming a few days ago.
In the first image, the La la Land star is unrecognisable in full costume complete with Cruella’s iconic black and white hair.
She is holding three Dalmatians on leads while co-stars Joel Fry and Paul Walter Hauser lurk in the background.
Cruella will take a 1970s punk-rock approach, according to producers.
Sean Bailey, Disney’s president of production, said the film will ask where de Vil’s dislike of animals comes from.
Speaking at D23, Disney’s biennial convention, he said: “How did she get that way, and how did she get so cruel?”
Stone could not appear in person at the convention, instead sending fans a video message from London.
Dame Emma Thompson will also appear in Cruella, which is due to be released on 28 May 2021.